After graduating from Byrnes High School, Marcus signed with the University of South Carolina to play football for Coach Steve Spurrier. Marcus was a three year letterman for the Gamecocks and led the team to their first Southeastern Conference championship game in 2010 as the starting running back. Again, Marcus was recognized for several awards during his college football career including: SEC Academic Honor Roll, SEC Freshman of the Year (2010), Sporting News NCAA Freshman of the Year (2010), First-Team All-SEC (2010), Second-Team All-American (2010), Second-Team All-SEC (2011). Mr. Lattimore also set the South Carolina single-game rushing record of 246 yards against the Naval Academy on September 17, 2011 and set the South Carolina all-time record with 41 career touchdowns scored. Marcus competed at USC for three seasons and decided to forego his senior year.